75g sachet | powder
Promotes a state of calm and provides relief from symptoms of stress and mild anxiety.
An evidence based formulation of potent botanicals to promote a state of calm and provide relief from symptoms of stress and mild anxiety.
Whereas pharmacological anti-anxiety and anti-depressant agents target only a single neurotransmitter or physiological pathway, myCalm's combination of botanic ingredients act on the key neurotransmitters responsible for mood - serotonin, dopamine, noradrenaline and GABA. Additional beneficial effects include antioxidant and neurotrophic support.
myCalm's ingredients have been shown to exert an anti-fatigue effect that increases mental work capacity against a background of stress and fatigue, particularly in tolerance to mental exhaustion and enhanced attention.
Organic | non-GMO | gluten free | dairy free | soy-free | non-extract.
myCalm may be considered for the treatment of:
mild to moderate depression
mild to moderate anxiety
The ingredients in myCalm may also be considered for their adaptogenic benefits, i.e. substances that enhance the capacity for coping with various stressors. Studies on animals and isolated neuronal cells have revealed that adaptogens exhibit neuroprotective, anti-fatigue, anti-depressive, anxiolytic and nootropic effects a wells as central nervous system (CNS) stimulating activity.
Mode of Action
myCalm's combination of botanicals work synergistically to enhance neurotransmitter retention and promote neuron health.
St. John's Wort (Hypericum perforatum) - serotonergic, dopaminergic and noradrenergic
St. John's Wort containing hypericin and hyperforin has been used for centuries in traditional medicine for the treatment of anxiety, and mild to moderate depression. In the past years, its anti-depressant and neuroprotective properties have been extensively studied. St. John's Wort is most noted for its inhibition of reuptake of serotonin, dopamine, noradrenaline and gamma-aminobutyric acid (GABA) . A number of meta-analyses demonstrated comparable efficacy and safety when comparing St Johns Wort with pharmacological selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac) and sertraline (Zoloft) , , . In postmenopausal women St Johns Wort reduced depression and hot flashes . In a meta-analysis of animal models St. Johns Wort demonstrated cognitive enhancement effects . In animal models of chronic stress St John's Wort ameliorated the decrease in brain derived neurotrophic factor (BDNF) . In human cell lines BDNF expression increased on exposure to St John's Wort .
Ashwagandha (Withania somnifera) - GABAergic and serotonergic.
Ashwagandha is a traditional herb containing withanolides and withasomniferolides and has been used to subjectively reduce stress and promote wellbeing. Clinical trials have demonstrated that daily use of ashwagandha reduces cortisol and in males increases testosterone . It has been shown to decrease severity of obsessive-compulsive disorder symtoms . It improves sleep quality in subjects suffering from non-restorative sleep , helps manage insomnia  and also helps with improving sleep quality and mental alertness in older subjects . In patients with schizophrenia a clinical trial demonstrated reduced depression and anxiety with daily use of ashwagandha . Animal models indicate that ashwagandha mediates its beneficial effects by increasing GABA receptor activity , as well as serotonin receptor and transporter activity . In animal models the effects of sleep deprivation as measured by decreases in serotonin and dopamine were ameliorated with ashwagandha .
Gotu Kola (centella asiatica) - serotonergic and neurotrophic.
Gotu kola is a traditional medical herb containing isoprenoids and phenylpropanoid derivatives with a long application history in anti-inflammation and cognitive support. The benefits of gotu kola on cognition has been demonstrated in a number of studies including improvment of cognitive deficits following stroke , nootropic and anti-Alzheimers properties  and other beneficial neurological effects . In animals models provide insight into the mechanims of gotu kola's cognitive effects via serotonin increase activity  which provides pain relief from migraine  and confers antidepressant effects . Animals studies have also demonstrated gotu kola increases hippocampal BDNF , increases BDNF-mediated cognitive performance  and alleviates chronic stress BDNF depletion .
Pomegranate (punica granatum) - serotonergic and neuroprotective.
The pomegranate fruit is a rich source of phytochemicals with high antioxidant and anti-inflammatory activity, possessing numerous health benefits. More recently it has also been found to support serotonin activity. Urolithin A, a metabolite of pomegranate, enhances serotonergic production in neurons . In animal models of menopause, pomegranate produces antidepressant-like effects via the serotonergic system ,. Clinical trials have reported daily consumption of pomegranate juice in older adults reduces cognitive decline  and improves memory . Ellagic acid, a component of pomegranate confers neuroprotection . Meta-analyses have found that pomegranate significantly reduces the pro-inflammatory cytokine, IL-6 , C-reactive protein (as hs-CRP) and Tumor necrosis alpha (TNFa) .
All ingredients are certified organic. There are no inactive ingredients present. There are no additives, flavours, preservatives or fillers. No extracts are used.
Use of the entire plant component
According to the current state of scientific knowledge several groups of active compounds are contributing to the efficacious properties of each of the botanical ingredients and in some cases they have not been definitively characterised. Therefore MyGene's position is to retain the entire plant component wherever possible rather than rely on plant extracts.
Organically derived materials
Organically grown plants have not been exposed to human-made pesticides, fertilizers or genetically modified organisms (GMOs) and thus avoid such contaminants, which in some cases have been found to contribute to cancer risk , birth defects  and hormone dysfunction . Research has also shown that organically grown plants contain significantly higher quantities of beneficial nutrients such as antioxidants . MyGene sources organic ingredients from certified producers whenever possible.
MyGene is committed to supporting environmentally sustainable and ethical practices.